Research
Energy balance
SIRT1 activation in the hypothalamus regulates energy metabolism and circadian rhythms, influencing susceptibility to diet-induced obesity and metabolic disorders.
Diet and exercise influence brain SIRT1 levels, which in turn regulate hunger and energy expenditure. This suggests that lifestyle interventions work partly by modulating central brain mechanisms, not just peripheral calorie burning.
GoodSupportsHIGH confidence
SIRT1 activities in these neurons influence the development of aging-associated metabolic disorders... SIRT1 suppresses the expression of orexigenic AgRP... Conditional knock-out of SIRT1 in POMC neurons... was shown to reduce energy expenditure and increase susceptibility to diet-induced obesity.
Why this rating
Supported by conditional knockout and overexpression studies in mice.
Source
SIRT1 in the brain—connections with aging-associated disorders and lifespan
Fanny Ng · Frontiers in Cellular Neuroscience · 2015
DOI 10.3389/fncel.2015.00064
narrative_reviewCited 185×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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