Mixed
The age-related accumulation of oxidized proteins impairs cellular proteolytic systems (proteasomes and lysosomes), creating a feedback loop that accelerates aging and contributes to age-related diseases.
Aging involves the accumulation of damaged proteins that can clog cellular cleanup systems. While this paper focuses on the mechanism rather than a specific diet or exercise protocol, it suggests that maintaining protein homeostasis (through adequate repair mechanisms and potentially reducing oxidative stress) is key to slowing age-related decline. Focus on healthy lifestyle factors that reduce oxidative stress.
Oxidation of proteins leads to a partial unfolding and, therefore, to aggregation. Protein aggregates impair the activity of cellular proteolytic systems (proteasomes, lysosomes), resulting in further accumulation of oxidized proteins.
Why this rating
This is a review article summarizing various studies; it cites evidence but does not present new primary clinical trial data.
Source
Protein Oxidation in Aging: Does It Play a Role in Aging Progression?
Sandra Reeg et al. · Antioxidants and Redox Signaling · 2014
DOI 10.1089/ars.2014.6062
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