Research
Hormonal
Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to aging and age-related diseases by promoting chronic inflammation and tissue dysfunction.
Senescent cells accumulate with age and contribute to inflammation and tissue dysfunction. Emerging therapies aim to clear these cells (senolytics) to improve healthspan.
GoodSupportsHIGH confidence
Senescent cells become a veritable factory of inflammatory cytokines, producing high levels of potent, pleiotropic molecules such as IL-6, IL-8, TNF-α, and VEGF-a, with profound effects on local inflammation, angiogenesis, fibrosis, and wound healing.
Why this rating
Strong evidence from multiple studies showing accumulation of senescent cells with age and their detrimental effects.
Source
Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher B. Newgard et al. · Journal of Clinical Investigation · 2013
DOI 10.1172/jci68833
narrative_reviewCited 185×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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