Research
Mixed
High-salt diets can enhance antitumor immunity in melanoma and lung cancer by promoting the differentiation of M1-like macrophages and increasing the infiltration and function of CD8+ T cells.
For patients with melanoma or lung cancer, high-salt intake might boost immune response, but this is a complex trade-off. Do not increase salt intake without consulting your oncologist, as it may not be suitable for everyone, especially those with heart conditions.
ModerateSupportsMEDIUM confidence
High-salt diet... is noteworthy due to its potential impact on tumor biology... M1-like macrophages↑, M1-like macrophages linked proteins (CXCL11/I-TAC, IL-1α, IL-1β, IL-12p40, M-CSF, and IL-17A) ↑, CD8+ T cells↑, granzyme B+CD8+ T cells↑, IFNγ+CD8+ T cells↑
Why this rating
Based on preclinical studies summarized in a review.
Source
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Yu-Ling Xiao et al. · Signal Transduction and Targeted Therapy · 2024
DOI 10.1038/s41392-024-01771-x
narrative_reviewCited 184×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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