Mixed
Endurance exercise training induces fiber-type-specific proteomic adaptations in human skeletal muscle, with slow-twitch fibers showing greater remodeling (237 proteins) than fast-twitch fibers (172 proteins), particularly in mitochondrial metabolism and calcium signaling.
Endurance training changes your muscles at a molecular level, but it doesn't do so uniformly. Slow-twitch fibers (used for endurance) remodel more extensively than fast-twitch fibers (used for speed/power). This means that to optimize overall fitness, you need to target different fiber types with different training modalities, as general endurance training primarily drives adaptations in slow-twitch fibers.
In response to 12 weeks of endurance exercise training, we found 237 and 172 proteins that were significantly regulated in slow- and fast-twitch muscle fibers, respectively... We observed greater adaptation to exercise training in slow-twitch (237 proteins) as opposed to fast-twitch fibers (172 proteins).
Why this rating
High-quality proteomic analysis with rigorous statistical controls (FDR, significance scores) on a small but well-characterized human cohort (n=5).
Source
Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Atul S. Deshmukh et al. · Nature Communications · 2021
DOI 10.1038/s41467-020-20556-8
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