Research
Hormonal
MuRF1 and MuRF2 function cooperatively to downregulate anabolic stretch signals (ANP, MLP) and translational machinery (mTOR pathway) in muscle tissue.
This paper identifies the specific molecular pathway (MuRF1/2 -> mTOR/Stretch signals) that controls muscle growth. Understanding this pathway is crucial for developing future drugs to treat muscle wasting diseases, but no such drugs are currently available for human use.
StrongSupportsVERY_HIGH confidence
Our data demonstrate that combined inactivation of MuRF1 and MuRF2 leads to chronic upregulation of stretch signals in both heart and skeletal muscle and failure to downregulate them.
Why this rating
Detailed molecular analysis including Western blots, gene expression profiling, and functional assays in a robust mouse model.
Source
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2
Christian Witt et al. · The EMBO Journal · 2007
DOI 10.1038/sj.emboj.7601952
mechanism_onlyCited 184×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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