Energy balance

Inhibition of MuRF1 and MuRF2 prevents age-related body fat accumulation in mice, resulting in a lean phenotype despite increased muscle mass.

In mice, blocking MuRF1/2 prevents fat gain during aging. This is likely due to the high energy cost of maintaining larger muscles and potentially direct effects on fat metabolism. This is not a current human intervention, but it suggests that increasing muscle metabolic activity might help manage body fat.