Mixed
NRPT supplementation (specifically the double dose) improves physical mobility markers, including chair stand tests and 6-minute walk distance, in older adults.
If you are looking to support physical mobility, the double dose of NRPT (500mg NR + 100mg PT) showed improvements in walking distance and chair stand tests in this study. However, this effect was not seen at the standard dose, so the higher dose may be necessary for this specific benefit.
Interestingly, the NRPT 2X group showed a significant within-group increase in mobility in both the 30-s chair test... and the 6-min walk test... at 60 days compared to baseline.
Why this rating
Statistically significant within-group changes were observed, but the authors note the study may not have been sufficiently powered to make unequivocal conclusions on secondary endpoints.
Source
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
Ryan W. Dellinger et al. · npj Aging and Mechanisms of Disease · 2017
DOI 10.1038/s41514-017-0016-9
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →