Research

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Endurance training increases neuromuscular junction (NMJ) size and complexity (branching and AChR area) in young adults, whereas in aged adults, it primarily reverses age-induced expansion and fragmentation.

Exercise affects your nerve-muscle connections differently as you age. In youth, it builds larger, more complex connections. In older age, it works to fix the wear-and-tear (fragmentation) of these connections, bringing them back to a healthier, younger baseline rather than building them larger.

GoodQualifiesHIGH confidence
among young adults endurance training elicits an expansion of NMJ dimensions... In contrast... aged rats performed endurance training, the effect was to reduce NMJ dimensions back to those observed in untrained young NMJs.
Rüdiger Rudolf et al. · Frontiers in Aging Neuroscience · 2014

Why this rating

Consistent findings across multiple rodent studies; human data is sparse.

Source

Degeneration of Neuromuscular Junction in Age and Dystrophy

Rüdiger Rudolf et al. · Frontiers in Aging Neuroscience · 2014

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