Research

Energy balance

Low-T3 syndrome in exercising women is induced abruptly when energy availability falls below a threshold of 19.0–25.0 kcal/kg lean body mass per day, regardless of exercise volume or intensity.

If you exercise regularly, your thyroid health depends on 'energy availability'—the calories you eat minus the calories you burn in exercise. If this number drops below roughly 30 kcal per kg of lean body mass, your body may switch into 'low-T3 syndrome,' slowing metabolism. To prevent this, you must either eat more to cover your exercise costs or reduce your exercise volume, as simply eating more without covering the exercise cost may not be enough if the gap is too wide.

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The results clearly demonstrated that the energy cost of aerobic exercise can induce low-T3 syndrome in exercising women within 4 days and that this effect can be prevented in exercising women by increasing their dietary energy intake without reducing either the volume or the intensity of an exercise regimen.
Anne B. Loucks et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1994

Why this rating

Randomized controlled trial with strict dietary control and direct manipulation of energy availability in a homogeneous population.

Source

Induction of low-T3 syndrome in exercising women occurs at a threshold of energy availability

Anne B. Loucks et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1994

DOI 10.1152/ajpregu.1994.266.3.r817

rct · n=27Cited 184×
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DOI resolved against Crossref · corpus check 2026-06-10

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