Research
Energy balance
Caloric restriction (CR) without malnutrition extends healthspan and lifespan across multiple species by modulating nutrient-sensing pathways such as mTORC1, AMPK, and Sirtuins.
To potentially extend healthspan, reduce your caloric intake by 20-30% below your maintenance level without sacrificing essential nutrients. Focus on nutrient-dense foods to avoid malnutrition while triggering metabolic adaptations like autophagy and improved insulin sensitivity.
GoodSupportsHIGH confidence
Calorie restriction (CR) without malnutrition was put forward long time ago, and was demonstrated to prolong lifespan in rats in 1935... nutrition-mediated mechanisms increasing healthspan and lifespan are discovered.
Why this rating
Supported by extensive pre-clinical data (yeast to primates) and clinical trials, though human longevity data is less definitive than animal models.
Source
Dietary regulation in health and disease
Qi Wu et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01104-w
narrative_reviewCited 183×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Ketogenic diets, characterized by high fat and low carbohydrate intake, improve metabolic health and reduce body weight by shifting metabolism towards fatty acid oxidation and ketone production.Good
- Intermittent fasting and time-restricted feeding activate AMPK and improve health outcomes by mimicking some benefits of caloric restriction without necessarily reducing total calories.Good
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