Research
Energy balance
PPARα activation promotes fatty acid oxidation and energy expenditure, particularly in the liver and brown adipose tissue, contributing to the treatment of hypertriglyceridemia and obesity-induced insulin resistance.
PPARα activation (e.g., via fibrates) can help manage high triglycerides and improve energy expenditure. This is particularly relevant for those with metabolic syndrome.
ModerateSupportsHIGH confidence
Through its prooxidative anti lipotoxic effects, PPARα ligands are successfully used therapeutically to treat primary and secondary forms of hypertriglyceridemia particularly associated with MetS... activation of PPARα in obese mice increases energy expenditure and activates thermogenic pathways that facilitate weight loss.
Why this rating
Review of mechanistic studies and clinical use of fibrates.
Source
PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity
Patricia Corrales et al. · International Journal of Molecular Sciences · 2018
DOI 10.3390/ijms19072124
narrative_reviewCited 182×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Activation of PPARγ (via agonists like TZDs or endogenous upregulation) improves insulin resistance and metabolic homeostasis by enhancing adipose tissue expandability, reducing ectopic lipid accumulation, and promoting browning, rather than solely by reducing fat mass.Moderate
- PPARβ/δ activation reduces systemic inflammation and promotes fatty acid oxidation in skeletal muscle and brown adipose tissue, offering potential therapeutic benefits for obesity and insulin resistance.Moderate
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