Research
Hormonal
Rapamycin analogs (everolimus and temsirolimus) inhibit mTORC1 effectively but have a reduced impact on glucose tolerance compared to rapamycin.
If considering mTOR inhibition for longevity, discuss rapamycin analogs like everolimus or temsirolimus with your doctor. These drugs may provide similar anti-aging benefits (mTORC1 inhibition) with a lower risk of causing glucose intolerance compared to rapamycin.
GoodSupportsHIGH confidence
Both everolimus and temsirolimus efficiently inhibited mTORC1 signaling, but had a reduced impact on glucose homeostasis compared to rapamycin.
Why this rating
Controlled animal study with clear mechanistic endpoints.
Source
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
Sebastian I. Arriola Apelo et al. · Aging Cell · 2015
DOI 10.1111/acel.12405
mechanism_onlyCited 182×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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