Micronutrients & recovery
Obese women exhibit altered caffeine metabolism, specifically excreting significantly higher amounts of the metabolite theobromine compared to lean women, despite similar caffeine excretion levels.
Obese individuals metabolize caffeine differently, producing more theobromine. This metabolic difference may contribute to the blunted thermogenic response observed in obesity, suggesting that standard caffeine dosing may not yield identical metabolic effects across different body compositions.
Whereas urinary caffeine excretion was similar in both groups, obese women excreted more theobromine, theophylline, and paraxanthine than lean women.
Why this rating
High-quality measurement via HPLC of urinary metabolites in a controlled crossover design.
Source
Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women
David Bracco et al. · American Journal of Physiology-Endocrinology and Metabolism · 1995
DOI 10.1152/ajpendo.1995.269.4.e671
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