Research
Mixed
Lower socioeconomic status (higher Townsend Deprivation Index) significantly amplifies the genetic effect on BMI.
For those with high genetic risk for obesity, socioeconomic factors like deprivation can amplify the genetic effect on BMI. Addressing socioeconomic barriers may be as important as lifestyle changes in mitigating genetic risk.
StrongQualifiesVERY_HIGH confidence
Higher TDI corresponds to a larger degree of social deprivation and was associated with an increased effect of GSBMI
Why this rating
Large sample size, replication, highly significant p-value (4.66*10^-11).
Source
Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status
Mathias Rask‐Andersen et al. · PLoS Genetics · 2017
DOI 10.1371/journal.pgen.1006977
cohort · n=362496Cited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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