Mixed
Dietary polyphenols, specifically (-)-epicatechin and olive-derived polyphenols, extend healthspan and lifespan in animal models by enhancing mitochondrial function, reducing oxidative stress, and modulating inflammatory pathways.
Focus on consuming polyphenol-rich whole foods like cocoa, olive oil, berries, and tea as part of a balanced diet. While supplements exist, the evidence for extending human lifespan is strongest when derived from food sources, particularly in older adults or those with metabolic issues. Do not expect immediate results; these are long-term preventive strategies.
EC may be a novel food-derived, anti-aging compound with direct lifespan-extending effect... olive oil polyphenols might have the potential to extend lifespan... polyphenols may protect cells from oxidative stress by multiple mechanisms.
Why this rating
Strong animal/in vitro evidence, but human data is observational or small-scale clinical trials; no large RCTs for lifespan extension.
Source
Dietary Anti-Aging Polyphenols and Potential Mechanisms
Jing Luo et al. · Antioxidants · 2021
DOI 10.3390/antiox10020283
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