Hormonal
Central nervous system (CNS) activation of GLP-1 receptors directly reduces peripheral lipid deposition in white adipose tissue (WAT) by modulating sympathetic nervous system (SNS) outflow, independent of changes in food intake.
Central GLP-1 signaling can directly tell fat cells to store less fat, independent of how much you eat. This happens through the sympathetic nervous system. However, this direct fat-reducing signal is lost in obesity, meaning this mechanism may not work for people who are already obese.
Intracerebroventricular infusion of GLP-1 in mice directly and potently decreases lipid storage in white adipose tissue. These effects are independent from nutrient intake.
Why this rating
Robust experimental design with multiple controls (pair-fed, TKO mice) and direct nerve recordings, but conducted in mice.
Source
Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity
Rubén Nogueiras et al. · Journal of Neuroscience · 2009
DOI 10.1523/jneurosci.5977-08.2009
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