Research
Hormonal
The ability of CNS GLP-1 to reduce fat storage is blunted in diet-induced obesity (DIO) due to a loss of sympathetic nervous system signaling to adipocytes.
In obese individuals, the brain's direct signal to burn fat via GLP-1 is blocked. This suggests that treatments relying solely on this pathway may be less effective for weight loss in obese people unless the resistance is overcome.
GoodRefutesHIGH confidence
Furthermore, the effects of CNS GLP-1 on adipocyte metabolism were blunted in diet-induced obese mice.
Why this rating
Clear demonstration of resistance in DIO mice using genetic models (TKO) and direct measurements.
Source
Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity
Rubén Nogueiras et al. · Journal of Neuroscience · 2009
DOI 10.1523/jneurosci.5977-08.2009
mechanism_onlyCited 180×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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