Research
Hormonal
Dehydroepiandrosterone (DHEA) levels are not associated with the risk of incident type 2 diabetes in postmenopausal women.
Unlike testosterone, estradiol, and SHBG, DHEA levels do not appear to predict diabetes risk in postmenopausal women. You do not need to monitor or target DHEA for diabetes prevention.
GoodRefutesHIGH confidence
Dehydroepiandrosterone had no relationship with incident T2DM.
Why this rating
Prospective cohort with rigorous adjustment.
Source
The Association of Endogenous Sex Hormones, Adiposity, and Insulin Resistance with Incident Diabetes in Postmenopausal Women
Rita R. Kalyani et al. · The Journal of Clinical Endocrinology & Metabolism · 2009
DOI 10.1210/jc.2009-0910
cohort · n=1612Cited 180×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In postmenopausal women, higher levels of bioavailable testosterone are associated with an increased risk of incident type 2 diabetes, but this association is entirely mediated by adiposity (BMI) and insulin resistance.Good
- In postmenopausal women, higher levels of estradiol (E2) and lower levels of sex hormone-binding globulin (SHBG) are associated with an increased risk of incident type 2 diabetes, and these associations persist even after adjusting for adiposity and insulin resistance.Good
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