Mixed
Acarbose treatment in prediabetic patients selectively modulates gut microbiota by increasing beneficial taxa (Lactobacillus, Dialister) and decreasing potentially harmful taxa (Ruminococcus, Butyricicoccus), which correlates with improved metabolic markers such as reduced triglycerides and insulin levels.
If you have prediabetes, acarbose may help improve your metabolic profile by changing your gut bacteria. It works by increasing beneficial bacteria like Lactobacillus and Dialister while reducing others. To avoid stomach upset, start with a low dose and gradually increase it over the first week. Take it with the first bite of your meals.
This study suggests that the benefits of acarbose for T2DM may correlate with the selective modulation of the gut microbiota.
Why this rating
Randomized, double-blind, controlled crossover trial with 40 completers, though sample size is modest and duration is short.
Source
Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial
Xiuying Zhang et al. · Diabetes Therapy · 2017
DOI 10.1007/s13300-017-0226-y
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