Mixed
A 12-week dietary intervention using a portfolio of functional foods (high-fibre, polyphenol-rich, vegetable-protein) significantly reduces metabolic endotoxaemia (LPS), improves glycaemic control (HbA1c, glucose AUC), and attenuates dyslipidaemia in patients with type 2 diabetes by modifying faecal microbiota (increasing Faecalibacterium prausnitzii and Akkermansia muciniphila, decreasing Prevotella copri).
For people with Type 2 Diabetes, incorporating a specific mix of functional foods—specifically dehydrated nopal, chia seeds, soy protein, and inulin—into a reduced-calorie diet for 12 weeks can significantly improve blood sugar control, lower bad cholesterol and triglycerides, and reduce inflammation. This is achieved by positively shifting gut bacteria, increasing beneficial species like Akkermansia and Faecalibacterium, and decreasing harmful ones like Prevotella. This dietary strategy complements standard diabetes medications.
Dietary intervention with functional foods significantly modified faecal microbiota compared with P by increasing alpha diversity and modifying the abundance of specific bacteria... The DP group also exhibited significant reductions in areas under the curve for glucose, total and LDL cholesterol, FFAs, HbA1c (P < 0.05), triglycerides and CRP... Conclusion: Long-term adherence to a high-fibre, polyphenol-enriched and vegetable-protein-based diet provides benefits for the composition of faecal microbiota, and may offer potential therapies for improvement of glycaemic control, dyslipidaemia and inflammation.
Why this rating
Randomized, placebo-controlled, double-blind clinical trial, though with a relatively small final sample size (n=53) and high dropout rate.
Source
A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes
Isabel Vera et al. · Diabetes & Metabolism · 2018
DOI 10.1016/j.diabet.2018.09.004
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