Hormonal
Concurrent training for strength and endurance results in less adaptation (specifically reduced strength gains) compared to training for either modality alone, due to molecular interference between the PKB and AMPK signaling pathways.
If your primary goal is building muscle or strength, avoid long-duration endurance cardio immediately before or after your weights. If your primary goal is endurance, limit heavy resistance training. The molecular signals for muscle growth (PKB) and mitochondrial efficiency (AMPK) fight each other, so doing both optimally at the same time leads to inferior results for both.
The classic work of Hickson demonstrated that training for both strength and endurance at the same time results in less adaptation compared with training for either one alone: this has been described as the concurrent training effect.
Why this rating
Based on a seminal 1980 study by Hickson and subsequent molecular validation described in the paper.
Source
Training for Endurance and Strength
Keith Baar · Medicine & Science in Sports & Exercise · 2006
DOI 10.1249/01.mss.0000233799.62153.19
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