Hormonal
A single bout of heavy resistance exercise transiently elevates mRNA levels of myogenic regulatory factors (myogenin, MyoD, MRF4) in human skeletal muscle, suggesting their involvement in regulating hypertrophy and fiber-type transitions.
Performing heavy resistance training triggers immediate genetic signals in your muscles that help build size and change fiber types. You do not need to optimize anything other than performing the exercise with sufficient intensity (heavy loads) to trigger this response. The body's molecular machinery handles the rest during recovery.
The present study shows that myogenin, MyoD, and MRF4 mRNA levels are transiently elevated in human skeletal muscle after a single bout of heavy-resistance training, supporting the idea that the MRFs may be involved in regulating hypertrophy and/or fiber-type transitions.
Why this rating
Small sample size (n=6), short duration (single bout), and reliance on mRNA rather than protein or functional outcomes.
Source
Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle
Niklas Psilander et al. · Journal of Applied Physiology · 2003
DOI 10.1152/japplphysiol.00903.2002
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