Hormonal
A single bout of heavy resistance exercise decreases the mRNA content of the IGF-IEa isoform during the initial recovery phase (1-6 hours), while the MGF (IGF-IEc) isoform remains unaffected.
After heavy lifting, your body temporarily reduces the production of one specific type of IGF-I (IGF-IEa) in the first few hours, while maintaining the muscle-specific version (MGF). This is a normal part of the body's regulatory process and does not mean your muscle-building potential is compromised. Focus on consistent training rather than worrying about immediate molecular fluctuations.
The present study shows a 44% decrease in IGF-IEabc mRNA levels after resistance exercise... The fact that IGF-IEbc remained unchanged indicates that the decrease in IGF-IEabc was caused by a decrease in IGF-IEa.
Why this rating
Small sample size (n=6), conflicting with other studies (Bamman et al.), and reliance on mRNA data.
Source
Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle
Niklas Psilander et al. · Journal of Applied Physiology · 2003
DOI 10.1152/japplphysiol.00903.2002
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