Research
Macro partitioning
High intake of simple carbohydrates (sucrose, fructose) and high-fat diets disrupt PPAR-alpha and PPAR-gamma balance, leading to reduced beta-oxidation and increased lipogenesis, which drives NAFLD progression.
Both high-fat and high-sugar diets contribute to fatty liver. Reducing intake of added sugars (especially fructose and sucrose) and saturated fats helps restore the balance of PPAR-alpha and PPAR-gamma, reducing liver fat accumulation.
GoodRefutesHIGH confidence
Excessive intake of sucrose (32% of energy as sucrose) yielded similar effects to liver histology and PPAR expression... excessive sucrose supply, elicited 1.3-fold increase in hepatic steatosis coupled with 0.5 fold decrease in PPAR-alpha expression and 0.8 increase in SREBP-1c expression.
Why this rating
Consistent findings across multiple murine models of high-fat and high-sugar diets.
Source
Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease
Vanessa Souza‐Mello · World Journal of Hepatology · 2015
DOI 10.4254/wjh.v7.i8.1012
narrative_reviewCited 179×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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