Research
Hormonal
Geranylgeranyl diphosphate synthase (Ggpps) in the liver is required for the secretion of lipid-overload-responsive EVs; liver-specific deletion of Ggpps reduces adipose mass and improves glucose tolerance.
This identifies Ggpps as a key enzyme controlling liver-to-fat signaling. Future therapies might target Ggpps to modulate fat storage, but currently, maintaining liver health through diet is the primary way to manage this pathway.
GoodSupportsHIGH confidence
Geranylgeranyl diphosphate synthase (Ggpps) expression in liver is enhanced by lipid overload and regulates EV secretion through Rab27A geranylgeranylation.
Why this rating
Genetic knockout models provide strong causal evidence in mice.
Source
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Yue Zhao et al. · Nature Communications · 2020
DOI 10.1038/s41467-020-14450-6
mechanism_onlyCited 178×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Liver-derived extracellular vesicles (EVs) containing specific miRNAs (let-7e-5p, miR-210-3p, miR-31-5p) are secreted in response to lipid overload and directly target adipocytes to promote adipogenesis and lipogenesis, thereby remodeling adipose tissue.Good
- Specific miRNAs (let-7e-5p, miR-210-3p) packaged in liver-derived EVs directly target Pgc1α in adipocytes to inhibit mitochondrial biogenesis and promote lipid accumulation.Good
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