Research
Hormonal
Specific miRNAs (let-7e-5p, miR-210-3p) packaged in liver-derived EVs directly target Pgc1α in adipocytes to inhibit mitochondrial biogenesis and promote lipid accumulation.
This explains how liver signals suppress fat-burning (mitochondrial biogenesis) in fat cells. It suggests that high liver-to-fat signaling may contribute to obesity by actively suppressing fat oxidation.
GoodSupportsHIGH confidence
These data suggest that let-7e-5p directly targets Pgc1α to affect adipose remodelling.
Why this rating
Strong molecular evidence including luciferase assays and knockout models.
Source
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Yue Zhao et al. · Nature Communications · 2020
DOI 10.1038/s41467-020-14450-6
mechanism_onlyCited 178×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Liver-derived extracellular vesicles (EVs) containing specific miRNAs (let-7e-5p, miR-210-3p, miR-31-5p) are secreted in response to lipid overload and directly target adipocytes to promote adipogenesis and lipogenesis, thereby remodeling adipose tissue.Good
- Geranylgeranyl diphosphate synthase (Ggpps) in the liver is required for the secretion of lipid-overload-responsive EVs; liver-specific deletion of Ggpps reduces adipose mass and improves glucose tolerance.Good
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