Research
Micronutrients & recovery
Age-associated NAD+ decline is driven by two converging mechanisms: decreased biosynthesis (specifically reduced NAMPT expression) and increased consumption (specifically elevated PARP and CD38 activity due to DNA damage and aging).
NAD+ levels drop with age because your body makes less of it (due to lower NAMPT enzyme levels) and uses it up faster (due to DNA repair demands via PARP and other enzymes). This dual decline impairs cellular energy and repair mechanisms.
StrongSupportsHIGH confidence
The combination of decreased NAD+ biosynthesis and increased NAD+ consumption exacerbates the depletion of NAD+, causing a variety of age-associated pathophysiologies.
Why this rating
The paper cites multiple references (33, 36, 40, 45, 46) detailing the specific enzymatic pathways (NAMPT, PARP, CD38) responsible for the decline.
Source
NAD+ biosynthesis, aging, and disease
Sean Johnson et al. · F1000Research · 2018
DOI 10.12688/f1000research.12120.1
narrative_reviewCited 178×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →