Research
Micronutrients & recovery
Age-associated NAD+ decline is driven by two converging mechanisms: decreased biosynthesis (specifically reduced NAMPT expression) and increased consumption (specifically elevated PARP and CD38 activity due to DNA damage and aging).
NAD+ levels drop with age because your body makes less of it (due to lower NAMPT enzyme levels) and uses it up faster (due to DNA repair demands via PARP and other enzymes). This dual decline impairs cellular energy and repair mechanisms.
StrongSupportsHIGH confidence
The combination of decreased NAD+ biosynthesis and increased NAD+ consumption exacerbates the depletion of NAD+, causing a variety of age-associated pathophysiologies.
Why this rating
The paper cites multiple references (33, 36, 40, 45, 46) detailing the specific enzymatic pathways (NAMPT, PARP, CD38) responsible for the decline.
Source
NAD+ biosynthesis, aging, and disease
Sean Johnson et al. · F1000Research · 2018
narrative_reviewCited 178×
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