Mixed
Human longevity is determined by a combination of genetic factors (accounting for ~25% of variance) and lifestyle/environmental factors, with lifestyle interventions capable of modulating genetic pathways to extend healthspan.
Focus on lifestyle factors that mimic the effects of calorie restriction and efficient nutrient sensing, such as maintaining a healthy weight and eating nutrient-dense foods (like the Mediterranean diet). While you cannot change your genes, you can modulate their expression through epigenetic mechanisms to potentially extend your healthspan, not just your lifespan.
Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors... about 25 % of the variation in human longevity is due to genetic factors... interventions modulating the interaction between genetic background and environment is essential to determine the individual chance to attain longevity.
Why this rating
Based on a comprehensive review of family studies, twin studies, and model organism research, though human genetic association studies show low replication.
Source
Human longevity: Genetics or Lifestyle? It takes two to tango
Giuseppe Passarino et al. · Immunity & Ageing · 2016
DOI 10.1186/s12979-016-0066-z
More from this paper
- Calorie restriction and specific dietary patterns (e.g., low-protein/Mediterranean) extend lifespan and healthspan in model organisms and are associated with exceptional human longevity in specific geographic regions.Good
- Epigenetic modifications, particularly DNA methylation patterns, serve as accurate biomarkers of biological age and are influenced by both genetic background and lifestyle.Good
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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