Research
Hormonal
Testosterone supplementation in elderly men increases muscle mass and strength but carries significant side effects, including sleep apnea, thrombotic complications, and prostate cancer risk.
Testosterone therapy can increase muscle mass and strength in elderly men, but it is not a first-line treatment due to serious side effects like prostate cancer risk and blood clots. It should only be considered under strict medical supervision when benefits outweigh risks.
GoodQualifiesHIGH confidence
Testosterone supplementation in large amounts and at low frequency improves muscle defects with aging but has several side effects. Risks associated with testosterone therapy in older men include sleep apnea, thrombotic complications, and the increased risk of prostate cancer [69].
Why this rating
Supported by multiple human studies and systematic reviews cited in the paper.
Source
Sarcopenia and Age-Related Endocrine Function
Kunihiro Sakuma et al. · International Journal of Endocrinology · 2012
DOI 10.1155/2012/127362
narrative_reviewCited 177×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Resistance training combined with amino acid supplementation is the most effective current strategy to prevent age-related muscle wasting and weakness.Strong
- Myostatin inhibition via antibody administration significantly increases muscle mass and strength in aged animal models, representing a promising therapeutic strategy for sarcopenia.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →