Research
Hormonal
SIRT3 suppresses lipogenesis in hepatocytes by downregulating the expression of Stearoyl-CoA desaturase 1 (SCD1).
Reducing the intake of saturated fats and maintaining metabolic health may help regulate SCD1, a key enzyme in fat synthesis. This complements the autophagy mechanism by reducing the load of new fat entering the liver.
ModerateSupportsMEDIUM confidence
Moreover, SIRT3 reduced the expression of stearoyl-CoA desaturase 1, to suppress lipogenesis.
Why this rating
Supported by in vitro and in vivo data, but lacks human clinical validation.
Source
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity
Tian Zhang et al. · Cell Death and Differentiation · 2019
DOI 10.1038/s41418-019-0356-z
mechanism_only · n=10Cited 177×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Overexpression of the mitochondrial deacetylase SIRT3 protects hepatocytes from lipotoxicity by promoting both macroautophagy (lipophagy) and chaperone-mediated autophagy (CMA) through the activation of the AMPK-ULK1 pathway.Moderate
- SIRT3 enhances mitochondrial energetics by directly deacetylating long-chain acyl-CoA dehydrogenase and promoting lipid droplet dispersion on detyrosinated microtubules.Moderate
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