Research
Energy balance
SIRT3 enhances mitochondrial energetics by directly deacetylating long-chain acyl-CoA dehydrogenase and promoting lipid droplet dispersion on detyrosinated microtubules.
Improving mitochondrial health through exercise and metabolic conditioning may support the enzymes that break down fats for energy. This suggests that a healthy liver relies on both clearing fat (autophagy) and efficiently burning it (mitochondrial function).
ModerateSupportsMEDIUM confidence
In addition, SIRT3 overexpression promoted LDs dispersion on detyrosinated microtubules, and directly deacetylated long-chain acyl-CoA dehydrogenase to enhance mitochondrial energetics.
Why this rating
Supported by mechanistic studies in cell lines and mice.
Source
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity
Tian Zhang et al. · Cell Death and Differentiation · 2019
DOI 10.1038/s41418-019-0356-z
mechanism_only · n=10Cited 177×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Overexpression of the mitochondrial deacetylase SIRT3 protects hepatocytes from lipotoxicity by promoting both macroautophagy (lipophagy) and chaperone-mediated autophagy (CMA) through the activation of the AMPK-ULK1 pathway.Moderate
- SIRT3 suppresses lipogenesis in hepatocytes by downregulating the expression of Stearoyl-CoA desaturase 1 (SCD1).Moderate
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