Research
Energy balance
uPAR-targeting CAR T cells effectively treat metabolic syndrome induced by a high-fat diet in young mice, improving body weight, glucose tolerance, and insulin sensitivity.
In a mouse model of obesity, clearing senescent cells via CAR T therapy improved metabolic health and reduced body weight, even when the mice continued to eat a high-fat diet.
GoodSupportsHIGH confidence
At 20 d after infusion, mice treated with uPAR CAR T cells displayed significantly lower body weight, better fasting blood glucose levels and improvements in both glucose and insulin tolerance compared to controls.
Why this rating
Controlled animal study with clear metabolic endpoints.
Source
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Corina Amor et al. · Nature Aging · 2024
DOI 10.1038/s43587-023-00560-5
mechanism_onlyCited 177×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A single administration of senolytic CAR T cells targeting uPAR eliminates senescent cells in aged mice, resulting in improved glucose tolerance, reduced fasting glucose, and enhanced exercise capacity.Good
- Prophylactic administration of uPAR-targeting CAR T cells in young mice prevents the development of age-related metabolic dysfunction and maintains exercise capacity into old age.Good
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