Mixed
Activation of G-protein coupled receptor 120 (GPR120) by n-3 fatty acids (DHA, alpha-linolenic acid) attenuates the production of pro-inflammatory cytokines (TNF-alpha, IL-6, MCP-1) and prevents obesity-induced glucose intolerance and insulin resistance.
Incorporate n-3 fatty acids (found in fish, flax, walnuts) into your diet. They activate a specific receptor (GPR120) that reduces inflammation in fat and muscle tissue, helping to prevent insulin resistance, especially if you are prone to obesity.
Activation of GPR120 and beta-arrestin 2 by n-3 fatty acids (docosahexaenoic and alpha-linolenic acids) attenuates the production of TNF-alpha, IL-6, and macrophage chemoattractant protein-1... This anti-inflammatory effect seems to be important for the beneficial action of these fatty acids in the model of obesity induced by high-fat diet, preventing development of glucose intolerance, insulin resistance, and obesity.
Why this rating
Supported by animal models and receptor characterization, though human clinical trial data for specific GPR120 agonists is less emphasized than the mechanism itself.
Source
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
Sandro Massao Hirabara et al. · Journal of Biomedicine and Biotechnology · 2012
DOI 10.1155/2012/379024
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