Micronutrients & recovery

Maintaining cytoplasmic and mitochondrial NADPH levels is a critical pro-longevity strategy because NADPH drives the recycling of antioxidants (glutathione and thioredoxin) and declines with age, contributing to oxidative stress and tissue dysfunction.

Focus on supporting your body's natural ability to produce and maintain NADPH, rather than relying solely on over-the-counter antioxidant supplements. Strategies that support NAD+ levels (like exercise or specific dietary patterns that boost NAD+ precursors) may indirectly support NADPH pools, as NADP+ is synthesized from NAD+. The paper suggests that maintaining the balance of these redox couples is more critical for longevity than high-dose antioxidant supplementation alone.