Research
Hormonal
Low-protein diets (10-15% energy) result in a greater reduction in hsCRP compared to high-protein diets (25-30% energy) during weight maintenance, independent of glycemic index.
To further lower inflammation after weight loss, consider not over-consumption protein. A moderate protein intake (around 10-15% of calories) may support lower inflammatory markers (hsCRP) better than a high-protein diet, although lipid and blood pressure benefits were similar across protein levels.
StrongSupportsHIGH confidence
Groups on low-protein diets achieved a −0.25 mg/L greater reduction in high-sensitivity C-reactive protein (95% confidence interval, −0.59 to −0.17) than those on high-protein diets (P<0.001)
Why this rating
Large-scale RCT with robust statistical analysis.
Source
Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein and Glycemic Index on Cardiovascular Risk Factors
Özlem Gögebakan et al. · Circulation · 2011
DOI 10.1161/circulationaha.111.033274
rct · n=773Cited 175×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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