Hormonal
Consuming meals during the biological rest phase (night for humans) disrupts circadian lipid metabolism, leading to increased postprandial glucose, insulin, and triglycerides compared to daytime consumption.
Align your main meals with your active daytime hours. Avoid large meals late at night or during your biological night (e.g., 10 PM - 6 AM). This timing aligns with your body's natural ability to process lipids and glucose, reducing the risk of metabolic dysregulation and weight gain.
Laboratory studies in human subjects have shown that consumption of meals during the biological night results in increased postprandial glucose, insulin and TAG relative to daytime meals.
Why this rating
The paper cites multiple human laboratory studies (constant routine protocols) showing consistent metabolic dysregulation, though it is a review of existing literature rather than a single new trial.
Source
Circadian regulation of lipid metabolism
Joshua J. Gooley · Proceedings of The Nutrition Society · 2016
DOI 10.1017/s0029665116000288
More from this paper
- Circadian disruption of clock genes (e.g., Bmal1, Per, Cry loss) leads to abnormal metabolic phenotypes, including hyperlipidaemia, hepatic steatosis, and impaired glucose tolerance.Strong
- Restricting food intake to the active phase (daytime for mice, nighttime for humans) improves metabolic health, reduces body weight, and protects against obesity and hepatic steatosis, even without caloric restriction.Good
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