Research
Hormonal
Circadian disruption of clock genes (e.g., Bmal1, Per, Cry loss) leads to abnormal metabolic phenotypes, including hyperlipidaemia, hepatic steatosis, and impaired glucose tolerance.
Maintain a regular sleep-wake cycle and consistent meal times to support your body's internal clock. Disrupting this rhythm (e.g., through chronic shift work or erratic eating) may negatively impact your lipid and glucose metabolism.
StrongSupportsHIGH confidence
Disruption of the core molecular clock, either in the whole body or in specific metabolic tissues, can lead to abnormal energy balance and dysregulation of lipids.
Why this rating
Based on well-established mouse models of gene knockout, providing strong mechanistic evidence.
Source
Circadian regulation of lipid metabolism
Joshua J. Gooley · Proceedings of The Nutrition Society · 2016
DOI 10.1017/s0029665116000288
narrative_reviewCited 175×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Consuming meals during the biological rest phase (night for humans) disrupts circadian lipid metabolism, leading to increased postprandial glucose, insulin, and triglycerides compared to daytime consumption.Good
- Restricting food intake to the active phase (daytime for mice, nighttime for humans) improves metabolic health, reduces body weight, and protects against obesity and hepatic steatosis, even without caloric restriction.Good
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