Research
Hormonal
Prenatal exposure to tributyltin (TBT) permanently reprograms mesenchymal stem cells (MSCs) to favor adipogenesis over osteogenesis, leading to increased body fat and insulin resistance in offspring.
Avoid sources of tributyltin (TBT), such as contaminated seafood from areas with heavy marine shipping or old boat paint, and ensure home plumbing does not involve leaching organotins from PVC pipes, particularly for pregnant women.
GoodSupportsHIGH confidence
Prenatal TBT exposure diverted bone marrow derived MSCs preferentially toward the adipose lineage and away from the bone lineage in exposed mice (39) and in mouse MSCs, in vitro (40).
Why this rating
Well-supported in mouse models with corresponding human epidemiological links.
Source
Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals
Riann Jenay Egusquiza et al. · Endocrinology · 2020
DOI 10.1210/endocr/bqaa024
narrative_reviewCited 175×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Exposure to environmental obesogens (e.g., tributyltin, BPA, phthalates) increases susceptibility to obesity by altering developmental programming of stem cells and metabolic regulation, independent of caloric intake.Good
- Obesogens can induce transgenerational obesity through epigenetic modifications (DNA methylation, histone retention, non-coding RNA) that persist in unexposed generations.Moderate
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