Energy balance
Among patients receiving intensive lifestyle intervention, achieving ≥10% weight loss in the first year is associated with a significant reduction in all-cause mortality compared to the control group.
If you are doing an intensive lifestyle program for type 2 diabetes, aim for 10% weight loss in the first year, as this specific threshold is associated with lower mortality risk. However, even if you don't reach 10%, the health benefits for blood pressure, fitness, and quality of life are still valuable.
ILI participants who lost ≥10% at 1 year had a 21% reduced risk of mortality (HR 0.79 [95% CI 0.67, 0.94]; P = 0.007) relative to DSE.
Why this rating
Based on a post hoc observational analysis within a high-quality RCT; prone to selection bias and confounding.
Source
Effects of Intensive Lifestyle Intervention on All-Cause Mortality in Older Adults With Type 2 Diabetes and Overweight/Obesity: Results From the Look AHEAD Study
Rena R. Wing et al. · Diabetes Care · 2022
DOI 10.2337/dc21-1805
Related findings · Energy balance
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