Research
Energy balance
Calorie restriction (CR) of 25-30% without malnutrition improves cardiometabolic risk factors (body composition, lipids, glucose, inflammation) and may extend healthy lifespan.
Reduce your daily calorie intake by 25-30% while ensuring you still get all essential nutrients. This can be done continuously or via intermittent fasting patterns. Combining this with exercise yields the best cardiovascular outcomes.
GoodSupportsHIGH confidence
CR is generally defined as a dietary pattern that reduces average daily calorie intake by 25%–30% without affecting the intake of other essential nutrients... CR can extend the organism’s lifespan by reducing the basal metabolic rate (BMR), suppressing inflammation and oxidative stress, and improving insulin sensitivity.
Why this rating
Supported by CALERIE-1 and CALERIE-2 RCTs.
Source
Dietary patterns and cardiometabolic health: Clinical evidence and mechanism
Wenting Wang et al. · MedComm · 2023
DOI 10.1002/mco2.212
narrative_reviewCited 57×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Adhering to healthy dietary patterns, including calorie restriction, intermittent fasting, Mediterranean, and plant-based diets, significantly reduces the risk of cardiometabolic disease (CMD) and all-cause mortality.Good
- Gut microbiota composition and metabolites play a critical role in the crosstalk between dietary patterns and cardiometabolic health, suggesting personalized dietary strategies based on microbiota profiles.Moderate
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