Research
Mixed
The physical function benefits of intensive lifestyle intervention are not sustained in patients with a preexisting history of cardiovascular disease (CVD), who lose the initial advantage by the second year.
If you have Type 2 Diabetes and a history of heart disease, an intensive lifestyle program will still improve your physical function in the first year, but this benefit may not last as long as it does for those without heart disease. It is crucial to maintain the lifestyle changes aggressively, as the 'legacy effect' seen in others may not apply to you.
WeakRefutesHIGH confidence
By year 2, persons in ILI with preexisting cardiovascular disease were no different in PF than in DSE participants with preexisting cardiovascular disease... the presence of CVD at the time of the baseline assessment negatively influenced sustaining the benefit observed with ILI.
Why this rating
Large RCT with significant subgroup analysis.
Source
Aging and Physical Function in Type 2 Diabetes: 8 Years of an Intensive Lifestyle Intervention
W. Jack Rejeski et al. · The Journals of Gerontology Series A · 2014
DOI 10.1093/gerona/glu083
rct · n=5145Cited 56×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- An intensive lifestyle intervention (ILI) targeting weight loss and physical activity significantly improves and maintains self-reported physical functioning in older adults with type 2 diabetes compared to standard education, effectively buffering the age-related decline in function.Weak
- Older adults (median age > 58.8 years) derive significantly greater improvements in physical functioning from intensive lifestyle interventions than younger adults with Type 2 Diabetes.Weak
Related findings · Mixed
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