Mixed
Very Low Energy Diet (VLED) intervention (640 kcal/day for 12-16 weeks) significantly reduces disease activity in patients with Psoriatic Arthritis (PsA) and obesity, with greater weight loss correlating to greater clinical improvement.
For patients with PsA and obesity, a medically supervised Very Low Energy Diet (approx. 640 kcal/day) for 3-4 months can significantly reduce joint pain, skin psoriasis, and inflammation. The greater the weight lost, the better the improvement in disease activity. This should be done while keeping current arthritis medications stable.
Short-term weight loss treatment with VLED was associated with significant positive effects on disease activity in joints, entheses and skin in patients with PsA and obesity. A larger weight loss resulted in more improvement in a dose-response manner.
Why this rating
Single-arm interventional study without a control group; however, it demonstrates a clear dose-response relationship and significant statistical improvements.
Source
Weight loss improves disease activity in patients with psoriatic arthritis and obesity: an interventional study
Eva Klingberg et al. · Arthritis Research & Therapy · 2019
DOI 10.1186/s13075-019-1810-5
Related findings · Mixed
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