Hormonal
Elevated circulating levels of branched-chain amino acids (BCAAs: valine, leucine, isoleucine) are positively associated with insulin resistance (IR) and predict a higher risk of developing type 2 diabetes.
High blood levels of BCAAs are a strong warning sign for developing type 2 diabetes, especially in overweight individuals. This is likely due to your body's reduced ability to process these amino acids (impaired catabolism) rather than just eating too much protein. Focus on improving metabolic health through weight management and exercise to enhance your body's ability to clear BCAAs, rather than fearing dietary protein.
Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients.
Why this rating
Based on a systematic review of 23 observational and cohort studies involving over 20,000 participants, though heterogeneity prevents meta-analysis.
Source
The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review
Xue Zhao et al. · Journal of Diabetes Research · 2016
DOI 10.1155/2016/2794591
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