Hormonal
Supplementation with Lactobacillus gasseri or Lactobacillus johnsonii attenuates western diet-induced type 2 diabetes phenotypes in mice by improving hepatic mitochondrial health and reducing liver lipid accumulation.
If you are at risk for type 2 diabetes due to a high-sugar/high-fat diet, specific strains of Lactobacillus (L. gasseri and L. johnsonii) may help protect your liver's ability to process fats and manage blood sugar. They work by improving the health of liver mitochondria and increasing protective antioxidants like glutathione, rather than by changing your gut bacteria. This suggests that targeting liver health via specific probiotics could be a strategy for metabolic prevention.
Our gene expression and electron microscopy studies show that two species from Lactobacillus genus act upon mitochondria in the liver leading to the improvement of lipid metabolism.
Why this rating
Strong mechanistic evidence (transcriptomics, electron microscopy, metabolomics) and consistent in vivo results, but limited to murine models and specific strains.
Source
Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes
Richard R. Rodrigues et al. · Nature Communications · 2021
DOI 10.1038/s41467-020-20313-x
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →