Adherence
Replacing 30 minutes of sedentary time with moderate-to-vigorous physical activity (MVPA) significantly reduces cancer mortality risk by 31%, while replacing it with light-intensity physical activity (LIPA) reduces risk by 8%.
You don't need to run marathons to lower your cancer mortality risk. Simply swapping 30 minutes of sitting for 30 minutes of moderate exercise (like brisk walking) cuts your risk by 31%. Even swapping that time for light activity (like standing or slow walking) cuts risk by 8%. Prioritize breaking up sitting time with any form of movement.
Replacing 30 minutes of sedentary time with LIPA was significantly associated with an 8% (per 30 minutes: HR, 0.92; 95% CI, 0.86-0.97) lower risk of cancer mortality; MVPA was significantly associated with a 31% (per 30 minutes: HR, 0.69; 95% CI, 0.48-0.97) lower risk of cancer mortality.
Why this rating
Prospective cohort with objective measurement and robust statistical modeling (isotemporal substitution), though still observational.
Source
Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults
Susan C. Gilchrist et al. · JAMA Oncology · 2020
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