Energy balance

Mild depolarization of the inner mitochondrial membrane, mediated by mitochondria-bound hexokinases and creatine kinases, prevents the generation of mitochondrial reactive oxygen species (mROS) and is a crucial component of anti-aging mechanisms in long-lived mammals.

Longevity is linked to the ability of your cells to maintain 'mild depolarization' of mitochondria, a state where energy production is efficient enough to make ATP but low enough to prevent damaging ROS. This state is maintained by specific enzymes (hexokinases) bound to mitochondria. In short-lived animals, this mechanism fails with age, leading to oxidative damage. In long-lived animals, it persists. While you cannot directly 'dose' this mechanism, supporting mitochondrial health through exercise and metabolic flexibility may help preserve these kinase-mediated protective pathways.