Hormonal
Fasting-mimicking diets (FMD) and periodic fasting provide healthspan benefits and rejuvenate systems (like hematopoietic and neural) by mimicking physiological responses to fasting without complete food deprivation.
You can achieve some of the regenerative benefits of fasting (like stem cell renewal) without starving yourself by using a Fasting-Mimicking Diet. This involves consuming very low calories and protein for specific periods, which triggers the body's stress response and regeneration pathways. This approach may be more feasible for people who find traditional fasting too difficult.
A fasting-mimicking diet, consisting of very low calorie and protein that leads to similar physiological response to fasting... enhanced healthspan and rejuvenated the hematopoietic system while promoting adult neurogenesis.
Why this rating
Evidence is primarily from model organisms and specific human trials (Brandhorst et al.), but less broad than CR.
Source
Dietary restriction with and without caloric restriction for healthy aging
Changhan Lee et al. · F1000Research · 2016
DOI 10.12688/f1000research.7136.1
More from this paper
- Caloric restriction (20-40% reduction) extends healthspan and lifespan in model organisms and improves cardiometabolic markers in humans, but is associated with reduced bone mineral density.Good
- Dietary interventions that restrict specific macronutrients (particularly protein and amino acids) or utilize time-restricted feeding can extend healthspan and lifespan without requiring overall caloric restriction.Good
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