Mixed
Pyruvate dehydrogenase (PDH) transformation scales directly with exercise power output and closely matches the flux of carbohydrate oxidation into the mitochondria.
As you increase your cycling intensity from moderate to high (up to 90% VO2max), your body increasingly activates the PDH enzyme to process carbohydrates for energy. This activation scales with your effort, ensuring that the more you push, the more efficiently your mitochondria can use the pyruvate generated from glycogen.
Conversely, PDH transformation is directly related to the increasing power output and the calculated flux through the enzyme.
Why this rating
Controlled human trial with direct measurement of PDH activity and flux estimation.
Source
Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs
Richard A. Howlett et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1998
DOI 10.1152/ajpregu.1998.275.2.r418
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