Mixed
Plasma levels of CRAMP, EF-1α, stathmin, and chitinase enzyme activity serve as biomarkers for human aging and diseases associated with telomere shortening, correlating with biological age and disease severity.
If you are concerned about biological aging or chronic diseases like cirrhosis or MDS, blood tests measuring CRAMP, EF-1α, stathmin, and chitinase activity can provide a more accurate assessment of your biological age and disease risk than chronological age or standard markers like IL-6. These biomarkers increase with age and disease severity, offering a tool for personalized therapy planning.
The study shows that the expression level of these marker proteins increases in the blood plasma of aging humans and shows a further increase in geriatric patients with aging-associated diseases.
Why this rating
Strong evidence from multiple cohorts (mice, human fibroblasts, young/old humans, cirrhosis/MDS patients) with statistical validation (ROC curves, blinded tests).
Source
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
Hong Jiang et al. · Proceedings of the National Academy of Sciences · 2008
DOI 10.1073/pnas.0801457105
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